{"id":1641,"date":"2019-03-22T13:56:12","date_gmt":"2019-03-22T13:56:12","guid":{"rendered":"https:\/\/revisamed.com.br\/blog-wp-teste\/2019\/03\/22\/nanoparticulas-provocam-suicidio-de-celulas-cancerosas\/"},"modified":"2023-04-25T19:06:13","modified_gmt":"2023-04-25T19:06:13","slug":"nanoparticulas-provocam-suicidio-de-celulas-cancerosas","status":"publish","type":"post","link":"https:\/\/revisamed.com.br\/blog\/nanoparticulas-provocam-suicidio-de-celulas-cancerosas\/","title":{"rendered":"Nanopart\u00edculas provocam \u2018suic\u00eddio\u2019 de c\u00e9lulas cancerosas"},"content":{"rendered":"<h5 class=\"wp-block-heading\" id=\"h-pesquisa-e-desenvolvida-pela-ufrn\">Pesquisa \u00e9 desenvolvida pela <a href=\"https:\/\/www.ufrn.br\/\">UFRN<\/a><\/h5>\n<p>Nanopart\u00edculas provocam \u2018suic\u00eddio\u2019 de c\u00e9lulas cancerosas, aponta pesquisa. Apesar do avan\u00e7o da ci\u00eancia, o c\u00e2ncer ainda \u00e9 uma das doen\u00e7as mais temidas da humanidade. <\/p>\n<p>A Ag\u00eancia Internacional de Pesquisa em C\u00e2ncer, ligada \u00e0 Organiza\u00e7\u00e3o Mundial de Sa\u00fade (OMS), estimou 18 milh\u00f5es de novos casos no ano passado, com crescimento de 28% nos \u00faltimos seis anos. Isso significa que um em cada cinco homens e uma em cada seis mulheres no mundo desenvolver\u00e1 c\u00e2ncer durante a sua vida.<span style=\"font-size: inherit\">Por se tratar de uma doen\u00e7a de m\u00faltiplos fatores causada pelo ac\u00famulo de muta\u00e7\u00f5es gen\u00e9ticas que levam \u00e0 prolifera\u00e7\u00e3o anormal de tecidos, \u00e9 dif\u00edcil tra\u00e7ar um \u00fanico caminho para o tratamento do c\u00e2ncer.<\/span><\/p>\n<p><span style=\"font-size: inherit\"> Contudo, novo estudo publicado no\u00a0<\/span><em style=\"font-size: inherit\">New Journal of Chemistry\u00a0<\/em><span style=\"font-size: inherit\">por pesquisadores da Universidade Federal do Rio Grande do Norte (UFRN) abre caminhos para a realiza\u00e7\u00e3o de tratamentos mais efetivos usando o direcionamento de nanopart\u00edculas.<\/span><\/p>\n<figure class=\"wp-block-embed is-type-wp-embed is-provider-revisamed wp-block-embed-revisamed\">\n<div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"wp-embedded-content\" data-secret=\"TJ5JIHdKlg\"><p><a href=\"https:\/\/revisamed.com.br\/blog\/como-funciona-a-residencia-medica\/\">Guia Revisamed mostra como funciona a resid\u00eancia m\u00e9dica<\/a><\/p><\/blockquote>\n<p><iframe src=\"https:\/\/medprovas.com.br\/blog\/como-funciona-a-residencia-medica\/embed\/#?secret=sxOW5YDxfc#?secret=TJ5JIHdKlg\" title=\"\u201cGuia Revisamed mostra como funciona a resid\u00eancia m\u00e9dica\u201d \u2014 Revisamed\" class=\"wp-embedded-content\" width=\"600\" height=\"338\" frameborder=\"0\" loading=\"lazy\" referrerpolicy=\"strict-origin-when-cross-origin\"><\/iframe>\n<\/div>\n<\/figure>\n<p>A decodifica\u00e7\u00e3o da sequ\u00eancia do genoma humano possibilitou \u00e0 Ci\u00eancia localizar os genes mais frequentemente mutados diretamente correlacionados \u00e0s prote\u00ednas superexpressas no crescimento de tumores cancerosos. Isso foi fundamental no avan\u00e7o e aparecimento de novas pesquisas e tratamentos contra a doen\u00e7a. <span style=\"font-size: inherit\">Uma delas \u00e9 a terapia direcionada que permite atacar somente as c\u00e9lulas cancerosas, ao contr\u00e1rio da quimioterapia que tamb\u00e9m afeta as c\u00e9lulas normais e provoca muitos efeitos negativos \u00e0 sa\u00fade dos pacientes. Acontece que este tratamento \u00e9 ainda muito complexo e caro, o que dificulta sua populariza\u00e7\u00e3o.<\/span><\/p>\n<h5>Dez pesquisadores participam de estudos<\/h5>\n<p>Com o t\u00edtulo \u201cFuncionaliza\u00e7\u00e3o de nanopart\u00edculas de ouro com dois derivados de quinoxalina \u00e0 base de amino\u00e1lcool para direcionamento de fosfoinosit\u00eddeos 3-quinases (PI3K\u03b1)\u201d, a pesquisa foi desenvolvida na UFRN e envolveu os institutos de Qu\u00edmica (IQ-UFRN) e do C\u00e9rebro (ICe-UFRN), em parceria com os laborat\u00f3rios de Bioinorg\u00e2nica e Cristalografia, do departamento de Qu\u00edmica da UFSC, e de Microscopia Aplicada \u00e0 Ci\u00eancia da Vida, do Inmetro.<span style=\"font-size: inherit\">Ao todo, dez pesquisadores trabalharam no estudo: Janine Ara\u00fajo, Fabr\u00edcio Menezes, Heloiza Silva, Davi Vieira, S\u00e9rgio Ruschi Silva, Adailton Bortoluzzi, Celso Sant\u2019Anna, Mateus Eugenio, Jannyely Neri e Luiz Gasparotto, coordenador do estudo.<\/span><\/p>\n<h5 class=\"wp-block-heading\" id=\"h-novo-estudo\">Novo estudo<\/h5>\n<p>No novo estudo, os cientistas modificaram, de forma simplificada, nanopart\u00edculas de ouro atrav\u00e9s da inser\u00e7\u00e3o, em sua superf\u00edcie, de quinoxalinas sintetizadas. <\/p>\n<p>Al\u00e9m disso, usando simula\u00e7\u00e3o molecular (<em>in silico<\/em>), observaram que esta muta\u00e7\u00e3o permite atacar, com grande efici\u00eancia, c\u00e9lulas cancerosas por meio da terapia dirigida. Menores que 100 nan\u00f4metros, as nanopart\u00edculas de ouro s\u00e3o produzidas, como o pr\u00f3prio nome sugere, a partir do ouro.<span style=\"font-size: inherit\">Elas s\u00e3o t\u00e3o pequenas que podem, por exemplo, transportar medicamentos para o interior das c\u00e9lulas sem perfurar as membranas celulares. Tamb\u00e9m podem ser carreadas para partes espec\u00edficas do corpo humano em intervalos controlados. <\/span><\/p>\n<p><span style=\"font-size: inherit\">J\u00e1 as quinoxalinas s\u00e3o agentes antitumorais e anticancer\u00edgenos capazes de inibirem enzimas envolvidas na prolifera\u00e7\u00e3o, motilidade e diferencia\u00e7\u00e3o do c\u00e2ncer. Devido a sua vasta gama de aplica\u00e7\u00f5es que inclui luminesc\u00eancia e biomedicina, s\u00e3o identificadas algumas vezes como \u201cmol\u00e9culas reconhecedoras de tumores\u201d.<\/span><\/p>\n<h5 class=\"wp-block-heading\" id=\"h-autodestruicao-celular\">Autodestrui\u00e7\u00e3o celular<\/h5>\n<p>Segundo o professor Luiz Gasparotto, as nanopart\u00edculas de ouro se aquecem quando submetidas \u00e0 luz de determinados comprimentos de onda, o que pode instigar o suic\u00eddio celular a partir do calor. \u201cA ideia central \u00e9 concentrarmos nanopart\u00edculas de ouro na regi\u00e3o do tumor, de modo que a aplica\u00e7\u00e3o de luz aque\u00e7a a regi\u00e3o tumoral, levando apenas c\u00e9lulas doentes ao suic\u00eddio\u201d, explica.<\/p>\n<figure class=\"wp-block-image is-resized\"><img loading=\"lazy\" decoding=\"async\" loading=\"lazy\" src=\"https:\/\/revisamed.com.br\/blog\/wp-content\/uploads\/2019\/03\/ed79e58fa5b371b5-UFRN-1024x682-1.jpg\" alt=\"Nanopart\u00edculas provovam suic\u00eddio de c\u00e9lulas cancerosas\" class=\"wp-image-4698\" width=\"512\" height=\"341\"><\/figure>\n<p>A grande quest\u00e3o \u00e9 que as nanopart\u00edculas de ouro n\u00e3o sabem que devem colar apenas em c\u00e9lulas tumorais. \u00c9 neste ponto que entram as quinoxalinas. <\/p>\n<p>Estudos computacionais mostraram que duas quinoxalinas t\u00eam excelente afinidade por determinadas c\u00e9lulas tumorais e, por isso, \u201cgrudam\u201d muito bem em determinados tipos de c\u00e2nceres.<span style=\"font-size: inherit\">\u201cOs c\u00e1lculos te\u00f3ricos indicam uma forte tend\u00eancia de intera\u00e7\u00e3o dessas quinoxalinas com o s\u00edtio ativo da enzima-alvo, com os amino\u00e1cidos que apresentam as intera\u00e7\u00f5es mais fortes sendo iguais aos de outros ligantes j\u00e1 reportados na literatura\u201d, contextualiza S\u00e9rgio Ruschi, do Laborat\u00f3rio de Neurobiologia Celular e Molecular, do ICe-UFRN.<\/span><\/p>\n<h5 class=\"wp-block-heading\" id=\"h-entenda-a-metodologia\">Entenda a metodologia<\/h5>\n<p>Sabendo disso, os pesquisadores inseriram quinoxalinas na superf\u00edcie das nanopart\u00edculas para que estas fossem direcionadas a reconhecer os tumores.<\/p>\n<p> Um ponto importante neste trabalho \u00e9 o fato de as quinoxalinas serem produzidas em laborat\u00f3rio de maneira muito simples e barata, o que facilita sua produ\u00e7\u00e3o em larga escala.<span style=\"font-size: inherit\">A metodologia tipicamente utilizada \u00e9 a inser\u00e7\u00e3o de anticorpos na superf\u00edcie das nanopart\u00edculas, mas este \u00e9 um processo complexo, caro e muito sens\u00edvel. <\/span><\/p>\n<p><span style=\"font-size: inherit\">\u201cA grande contribui\u00e7\u00e3o deste trabalho \u00e9 em termos de simplicidade e custo. Mostramos que h\u00e1 um caminho interessante na produ\u00e7\u00e3o de compostos antitumorais. O fato de n\u00e3o usarmos anticorpos \u00e9 um excelente atalho para uma futura produ\u00e7\u00e3o em larga escala\u201d, diz Luiz Gasparotto.<\/span><\/p>\n<nav class=\"post-tags\" aria-label=\"Tags do conte\u00fado\"><a href=\"\/tag\/doencas\/\">Doen\u00e7as<\/a><a href=\"\/tag\/especialidades-medicas\/\">especialidades m\u00e9dicas<\/a><a href=\"\/tag\/oncologia\/\">Oncologia<\/a><a href=\"\/tag\/rio-grande-do-norte\/\">Rio Grande do Norte<\/a><\/nav>\n","protected":false},"excerpt":{"rendered":"<p>Nanopart\u00edculas provocam suic\u00eddio de c\u00e9lulas cancerosas, revela estudo publicado no New Journal of Chemistry pela UFRG. O Revisamed publica a pesquisa.<\/p>\n","protected":false},"author":2,"featured_media":1642,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[269,24,50,202],"rvm_specialty":[],"class_list":["post-1641","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","tag-doencas","tag-especialidades-medicas","tag-oncologia","tag-rio-grande-do-norte"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.7 (Yoast SEO v28.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Nanopart\u00edculas provocam \u2018suic\u00eddio\u2019 de c\u00e9lulas cancerosas | Blog Revisamed<\/title>\n<meta name=\"description\" content=\"Nanopart\u00edculas provocam suic\u00eddio de c\u00e9lulas cancerosas, revela estudo publicado no New Journal of Chemistry pela UFRG. 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